Antitubercular drugs induced hepatic oxidative stress and ultrastructural changes in rats
نویسندگان
چکیده
Methods The rats were divided into three groups (n=6 per group), group I served as a control, group II received orally combination of isoniazid (15mg/kg body weight), rifampicin (20mg/kg body weight) and pyrazinamide (35mg/kg body weight) daily for 45 days and group III received simultaneously Silymarin (50mg/kg body weight) and combination of anti-TB drugs at the above mentioned dosages for 45 days. After the experimental period, the levels of malondialdehyde (MDA, oxidative stress marker) and lipid profile was evaluated in serum. The data were analyzed by Duncan’s multiple range tests. The pathological and morphological changes were examined histologically and electron microscopically.
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